Related Experiment Video

Updated: Nov 2, 2025

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

798

Roles of lncRNA MAGI2-AS3 in human cancers

Liu Kai-Xin1, Cheng Cheng2, Li Rui1

  • 1Honghui-hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710054, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|June 14, 2021
PubMed

Insights

Long noncoding RNA MAGI2-AS3 (MAGI2-AS3) is crucial in human cancers, impacting progression and prognosis. This review details its roles in cancer development and its potential as a therapeutic target.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Long noncoding RNAs (lncRNAs) are key regulators in various cancers.
  • MAGI2 antisense RNA 3 (MAGI2-AS3) is frequently detected in human cancers.
  • MAGI2-AS3 expression correlates with cancer progression and patient outcomes.

Purpose of the Study:

  • To review the functions and mechanisms of MAGI2-AS3 in cancer.
  • To explore the clinical significance of MAGI2-AS3 in cancer development.
  • To highlight MAGI2-AS3 as a potential prognostic biomarker and therapeutic target.

Main Methods:

  • Literature review of current research on MAGI2-AS3.
  • Analysis of MAGI2-AS3's roles as a competing endogenous RNA (ceRNA).
  • Investigation of MAGI2-AS3's functions as an epigenomic and transcriptional regulator.

Main Results:

  • MAGI2-AS3 dysregulation affects cancer cell proliferation, apoptosis, invasion, and metastasis.
  • MAGI2-AS3 influences resistance to cancer treatments.
  • MAGI2-AS3 acts through diverse molecular mechanisms in cancer.

Conclusions:

  • MAGI2-AS3 is a significant player in human cancer development.
  • MAGI2-AS3 holds promise as a biomarker for cancer prognosis.
  • MAGI2-AS3 represents a potential target for novel cancer therapies.
Keywords:
BiomarkerLong noncoding RNAsMAGI2-AS3Target

More Related Videos

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos07:24

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos

Published on: December 13, 2018

6.6K
Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

7.8K

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.2K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.1K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.3K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
22.6K
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
12.3K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.0K