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Thromboinflammation in coronavirus disease 2019: The clot thickens

Raayma Iffah1, Felicity N E Gavins1

  • 1Department of Life Sciences, Centre for Inflammation Research and Translational Medicine (CIRTM), Brunel University London, London, UK.

British Journal of Pharmacology
|June 15, 2021
PubMed

Insights

The immune system

Area of Science:

  • Immunology
  • Pathophysiology
  • Virology

Background:

  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic presents a global health challenge.
  • Coronavirus disease 2019 (COVID-19) pathophysiology is complex, with significant implications for high-risk individuals.
  • Immune system's role in COVID-19, including thrombosis and inflammation, is a key area of research.

Purpose of the Study:

  • To understand the immune system's function in diverse COVID-19 patient cohorts.
  • To identify novel therapeutic targets for COVID-19.
  • To explore drug repurposing strategies for COVID-19 treatment.

Main Methods:

  • Analysis of immune system responses in COVID-19 patients.
  • Investigation of neutrophil and platelet activation.
  • Assessment of endothelial dysfunction in COVID-19.

Main Results:

  • Complex immune responses contribute to COVID-19 severity.
  • Neutrophil and platelet activation are implicated in COVID-19 pathophysiology.
  • Endothelial dysfunction plays a role in COVID-19 complications.

Conclusions:

  • Understanding immune system variations is crucial for managing COVID-19.
  • Research into immune responses can lead to new treatments and drug repurposing.
  • Further studies are vital for global health strategies against COVID-19.

Keywords:
inflammationneutrophilsplateletsresolution pharmacologythromboinflammationthrombosis

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