Recent updates on Wnt signaling modulators: a patent review (2014-2020)

Vishalgiri G Goswami1, Bhumika D Patel1

  • 1Department of Pharmaceutical Chemistry, Institute of Pharmacy, Nirma University, Ahmedabad, India.

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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
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