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Azole resistance in Aspergillus species: promising therapeutic options

Shirisha Pasula1, Pranatharthi H Chandrasekar2

  • 1Department of Internal medicine, Division of Infectious diseases, Detroit Medical Center/Wayne State University, Detroit, MI, USA.

Expert Opinion on Pharmacotherapy
|June 15, 2021
PubMed
Abstract

Insights

Azole resistance in Aspergillus infections is a growing global concern, driven by agricultural fungicide use. This resistance poses a significant challenge, with limited treatment options and high mortality rates.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Azoles are primary treatments for Aspergillus infections.
  • Agricultural fungicide use contributes to rising azole resistance worldwide.
  • Antifungal treatment selection is increasingly challenging due to resistance.

Purpose of the Study:

  • To review the epidemiology of azole resistance in Aspergillus.
  • To discuss mechanisms and detection methods for azole resistance.
  • To explore management strategies for azole-resistant Aspergillus infections.

Main Methods:

  • Literature review of epidemiology, resistance mechanisms, and detection.
  • Analysis of current and emerging antifungal agents.
  • Evaluation of clinical management strategies for resistant infections.

Main Results:

  • Azole resistance in Aspergillus is a significant global issue.
  • Resistance is linked to high mortality rates and limited therapeutic options.
  • Early suspicion and susceptibility testing are crucial for managing resistant cases.

Conclusions:

  • Global surveillance of azole resistance prevalence is essential.
  • Prompt identification of resistance is critical due to poor treatment outcomes.
  • New antifungal agents are under development to combat resistant Aspergillus strains.
Keywords:
AspergillosisAspergillus fumigatusAspergillus infectionazole resistancedrug resistant Aspergillusnew antifungal agents

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