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Predicting value of fibrinogen in identifying cerebrovascular ischemic events in patients with dizziness/vertigo
You Wang1, Xueling Zhou1, Yong Luo2
1Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Yuzhong District, 1 Youyi Road, Chongqing, 400016, China.
Insights
Elevated fibrinogen (FIB) levels may help identify cerebrovascular ischemic events in dizziness patients. This study suggests FIB is a useful biomarker for diagnosing stroke in those experiencing vertigo.
Area of Science:
- Neurology
- Biochemistry
- Clinical Diagnostics
Background:
- Dizziness and vertigo have diverse causes, including cerebrovascular ischemic events.
- Accurate identification of cerebrovascular events in patients with dizziness is clinically challenging.
Purpose of the Study:
- To assess the diagnostic value of plasma fibrinogen (FIB) levels in identifying cerebral ischemic events among patients presenting with dizziness or vertigo.
Main Methods:
- A cohort of 298 patients with dizziness/vertigo within 72 hours of symptom onset were analyzed.
- Plasma FIB levels were measured, and participants were categorized into cerebral ischemic event and non-cerebrovascular disease groups.
- Multivariate logistic regression and ROC curve analysis were used to evaluate FIB's predictive capability.
Main Results:
- Fibrinogen (FIB) was independently associated with cerebral ischemic events in dizziness patients (OR=1.84, p=0.010).
- A FIB cut-off value of 2.43 g/L demonstrated moderate predictive ability (AUC=0.658).
- A constructed nomogram indicated higher FIB levels correlate with increased risk of cerebral ischemic events (C-index=0.800).
Conclusions:
- Plasma fibrinogen may serve as a valuable biochemical marker for detecting cerebral ischemic events in patients with dizziness or vertigo.
- Further research can explore FIB's role in early stroke diagnosis and management.
Purpose:
Dizziness and vertigo are caused by multiple etiologies, including cerebrovascular ischemic events. However, identifying cerebrovascular ischemic events as a cause of dizziness and vertigo remains a challenge. We tried to assess the value of fibrinogen (FIB) in identifying of cerebral ischemic event in patients with dizziness/vertigo.
Methods:
The study enrolled patients with dizziness/vertigo presented within 72 h in a tertiary hospital. The plasma FIB levels were measured in all participants. According to the final diagnosis, participants were divided into cerebral ischemic events group and non-cerebrovascular diseases group. Multivariate logistic regression was performed to explore the association between FIB and cerebral ischemic events. The receiver operating characteristic curve was performed, and the nomogram was constructed to evaluate the overall prediction ability of FIB in cerebral ischemic event.
Results:
A total of 298 participants were enrolled in our study, of 126 cerebral ischemic events patients. Multivariate logistic regression analysis showed that FIB was independently associated with cerebral ischemic event in patients with dizziness (OR = 1.84, 95%CI [1.15, 2.92], p = 0.010). The cut-off value of FIB in predicting cerebral ischemic event was 2.43 g/L (AUC = 0.658). The nomogram showed that higher FIB level was associated with a greater risk of cerebral ischemic event (C-index = 0.800).
Conclusions:
Our study suggested that FIB may be a useful biochemical parameter for identifying cerebral ischemic event in patients with dizziness/vertigo.
