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Visual Evoked Potentials in Operated Primary Congenital Glaucoma: A Cross-Sectional Comparative Study

Mai A Mohammed1, Mohamed Saad Morsy1, Nashwa Shehata Zeater2

  • 1Ophthalmology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Clinical Ophthalmology (Auckland, N.Z.)
|June 17, 2021
PubMed

Insights

Operated primary congenital glaucoma (PCG) eyes showed normal visual evoked potential (VEP) parameters compared to healthy children. This suggests successful surgical control in PCG leads to comparable visual pathway function.

Area of Science:

  • Ophthalmology
  • Pediatric Ophthalmology
  • Neuro-ophthalmology

Background:

  • Primary congenital glaucoma (PCG) is a severe pediatric eye condition requiring surgical intervention.
  • Assessing visual pathway function post-surgery is crucial for understanding long-term outcomes.
  • Visual evoked potential (VEP) testing can evaluate the integrity of the visual pathway.

Purpose of the Study:

  • To evaluate visual evoked potential (VEP) parameters in surgically managed primary congenital glaucoma (PCG) eyes.
  • To compare VEP parameters between operated PCG eyes and age-matched healthy children's eyes.

Main Methods:

  • A cross-sectional comparative study included 26 children with operated PCG and 22 age-similar controls.
  • Standard ophthalmic examination and electrophysiological testing (single flash VEP) were performed.
  • VEP parameters analyzed included P2 implicit time and N1-P1, N2-P2 amplitudes.

Main Results:

  • No statistically significant differences were found in VEP parameters (P2 implicit time, N1-P1, N2-P2 amplitudes) between operated PCG eyes and control eyes.
  • The mean age of study participants and controls was comparable.
  • No significant correlation was observed between clinical characteristics and VEP parameters in PCG eyes.

Conclusions:

  • Surgically controlled primary congenital glaucoma (PCG) eyes demonstrate visual evoked potential (VEP) parameters similar to those of healthy children.
  • These findings suggest that successful surgical management of PCG results in normal visual pathway function as assessed by VEP.
Abstract

Keywords:
electrophysiologyoptic nerveprimary congenital glaucomavisual evoked potentials

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