Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

228
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
228
Nephrons01:10

Nephrons

4.3K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
4.3K
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

49
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
49
Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

91
Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
91
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

432
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
432
Renal Corpuscle01:20

Renal Corpuscle

4.7K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
4.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinico-epidemiological Profile of Patients with Chronic Kidney Disease of Unknown Etiology in Agricultural and Rural Communities of Eastern India: EICKI-INDIA Study.

Indian journal of public health·2026
Same author

Oncohypertension: Unraveling the Link Between Cancer and Hypertension.

Advances in kidney disease and health·2026
Same author

Clinically Silent Sjögren Syndrome Presenting With Cryoglobulinemia.

International journal of surgical pathology·2026
Same author

Torque teno virus DNA load as a clinical biomarker for immunosuppression and infection risk in early kidney transplantation: a prospective study.

Clinical transplantation and research·2026
Same author

Use of Banff 2018 Working Group Classes to Predict Outcomes Versus Use of Baseline Parameters of Renal Function and BK Viremia in BK Virus Nephropathy: A Retrospective Institutional Experience.

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation·2026
Same author

Granulomatosis with Polyangiitis (Wegener Granulomatosis) Presenting as a Pancreatic Mass: A Rare Malignancy Mimic.

The American journal of case reports·2026

Related Experiment Video

Updated: Nov 2, 2025

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis
04:37

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis

Published on: April 25, 2025

973

Nephrogenic systemic fibrosis: A frivolous entity.

Vinant Bhargava1, Kulwant Singh2, Priti Meena3

  • 1Department of Nephrology, Institute of Renal Science, SIR Ganga Ram Hospital, New Delhi 110060, India.

World Journal of Nephrology
|June 17, 2021
PubMed
Summary

Gadolinium-based contrast agents (GBCAs) are crucial for MRI imaging but can cause nephrogenic systemic fibrosis (NSF) in patients with kidney problems. Understanding NSF

Keywords:
Chronic kidney diseaseDialysisEnd stage kidney diseaseGadolinium-based contrast agentsMagnetic resonance imagingNephrogenic systemic fibrosis

More Related Videos

Refined Murine Model of Idiopathic Pulmonary Fibrosis
07:51

Refined Murine Model of Idiopathic Pulmonary Fibrosis

Published on: June 17, 2025

487
Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis
06:03

Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis

Published on: May 9, 2025

1.1K

Related Experiment Videos

Last Updated: Nov 2, 2025

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis
04:37

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis

Published on: April 25, 2025

973
Refined Murine Model of Idiopathic Pulmonary Fibrosis
07:51

Refined Murine Model of Idiopathic Pulmonary Fibrosis

Published on: June 17, 2025

487
Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis
06:03

Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis

Published on: May 9, 2025

1.1K

Area of Science:

  • Radiology and Medical Imaging
  • Nephrology
  • Dermatology

Background:

  • Gadolinium-based contrast agents (GBCAs) enhance MRI image quality for diagnosis.
  • Nephrogenic systemic fibrosis (NSF) is a serious adverse effect linked to GBCAs, particularly in patients with renal insufficiency.
  • NSF is a debilitating multisystem condition primarily affecting the skin, with potential internal organ involvement.

Purpose of the Study:

  • To explore the pathogenesis of NSF associated with GBCAs.
  • To identify risk factors for developing NSF.
  • To review current and potential treatment strategies for NSF.

Main Methods:

  • Literature review of case studies and clinical trials on GBCAs and NSF.
  • Analysis of reported NSF cases in patients with varying degrees of kidney function.
  • Examination of proposed mechanisms underlying NSF development.

Main Results:

  • NSF is strongly correlated with GBCA exposure in patients with severe kidney disease.
  • The condition is characterized by progressive skin induration and can affect internal organs.
  • Currently, no definitive cure for NSF exists, highlighting the need for preventative measures and further research.

Conclusions:

  • GBCAs are essential but carry a risk of NSF in renally impaired patients.
  • Further research into NSF pathogenesis, risk stratification, and therapeutic interventions is critical.
  • Careful patient selection and monitoring are necessary when using GBCAs in at-risk populations.