Anticancer activities, structure-activity relationship, and mechanism of action of 12-, 14-, and 16-membered

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Ruo Wang1

  • 1Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Archiv Der Pharmazie
|June 17, 2021
PubMed

Insights

Macrolactones show promise as anticancer agents, effectively targeting both drug-sensitive and multidrug-resistant cancers by inhibiting proliferation and metastasis. Further research into their structure-activity relationships and mechanisms can lead to novel cancer therapies.

Area of Science:

  • Medicinal Chemistry
  • Pharmacology
  • Oncology

Background:

  • Cancer remains a leading global cause of death, with drug resistance posing a significant challenge.
  • Novel chemotherapeutic agents are crucial for overcoming treatment limitations and improving patient outcomes.

Purpose of the Study:

  • To review advances in 12-, 14-, and 16-membered macrolactones with anticancer potential.
  • To summarize the structure-activity relationships of these macrolactones.
  • To discuss the anticancer mechanisms of macrolactones.

Main Methods:

  • Literature review of recent studies on macrolactone development.
  • Analysis of structure-activity relationships.
  • Compilation of data on anticancer mechanisms.

Main Results:

  • Macrolactones exhibit anticancer effects, including inhibition of proliferation, metastasis, and angiogenesis.
  • These compounds are effective against both drug-sensitive and multidrug-resistant cancer cells.
  • Rational design of macrolactones offers therapeutic potential.

Conclusions:

  • Macrolactones represent a promising class of compounds for cancer treatment.
  • Understanding their mechanisms and structure-activity relationships is key to developing new anticancer drugs.
  • Further investigation into macrolactones could yield valuable therapeutic interventions for various cancers.
Keywords:
anticancermacrolactonesmechanisms of actionstructure-activity relationship

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