Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Nov 1, 2025

Author Spotlight: Advancing Human Cardiac Anatomy Through Multi-Scale Analysis of Hearts
04:22

Author Spotlight: Advancing Human Cardiac Anatomy Through Multi-Scale Analysis of Hearts

Published on: June 28, 2024

700

Mapping the multiscale structure of biological systems.

Leah V Schaffer1, Trey Ideker1

  • 1Division of Genetics, Department of Medicine, University of California San Diego, San Diego, La Jolla, CA 92093, USA.

Cell Systems
|June 17, 2021
PubMed
Summary

This study introduces network proximity measures for creating multiscale hierarchical maps of biological systems. These maps enable functionalization for predictive modeling, linking genotype to phenotype across biological scales.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A genome-scale CRISPRi perturbation atlas of human induced pluripotent stem cells.

Nature biotechnology·2026
Same author

Harmonization and integration of pharmacogenomics screens.

Bioinformatics (Oxford, England)·2026
Same author

DREAM repressive activity links somatic mutation, lifespan and disease.

Nature aging·2026
Same author

A foundation model of cancer genotype enables precise predictions of therapeutic response.

Cancer discovery·2026
Same author

A tri-modal contrastive learning framework for protein representation learning.

Cell reports methods·2026
Same author

Common and rare genetic variants show network convergence for a majority of human traits.

EMBO reports·2026

Area of Science:

  • Systems Biology
  • Bioinformatics
  • Network Science

Background:

  • Biological systems exhibit inherent multiscale hierarchical structures, from molecules to tissues.
  • Diverse technologies generate large networks of biological unit proximities (e.g., protein-protein interactions, cell-cell relationships).

Purpose of the Study:

  • To review concepts and progress in using network proximity for multiscale hierarchical biological mapping.
  • To explore functionalization of these maps for predictive modeling and genotype-phenotype translation.

Main Methods:

  • Utilizing network proximity measures to construct hierarchical maps of biological systems.
  • Functionalizing these maps to develop predictive models.

Main Results:

Keywords:
community detectionhierarchical modelsmultiscalenetwork biologynetworksstructural biologystructuresystems biology

More Related Videos

3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol
10:14

3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol

Published on: May 12, 2019

7.4K
Mapping Mammalian 3D Genome Interactions with Micro-C-XL
11:41

Mapping Mammalian 3D Genome Interactions with Micro-C-XL

Published on: November 3, 2023

3.0K

Related Experiment Videos

Last Updated: Nov 1, 2025

Author Spotlight: Advancing Human Cardiac Anatomy Through Multi-Scale Analysis of Hearts
04:22

Author Spotlight: Advancing Human Cardiac Anatomy Through Multi-Scale Analysis of Hearts

Published on: June 28, 2024

700
3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol
10:14

3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol

Published on: May 12, 2019

7.4K
Mapping Mammalian 3D Genome Interactions with Micro-C-XL
11:41

Mapping Mammalian 3D Genome Interactions with Micro-C-XL

Published on: November 3, 2023

3.0K
  • Demonstrated the creation of multiscale hierarchical maps based on network proximity.
  • Showcased the functionalization of these maps for predictive applications, including genotype-phenotype translation.

Conclusions:

  • Network proximity offers a unified approach for analyzing biological data across multiple scales.
  • Multiscale hierarchical mapping facilitates a comprehensive understanding of biological systems from molecular to macroscopic levels.