Dynamic nanoassembly-based drug delivery system (DNDDS): Learning from nature.

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Drug Delivery Systems

Background:

• Dynamic nanoassembly-based drug delivery systems (DNDDS) are evolving for advanced disease diagnosis and therapy.
• Understanding dynamic nano-bio interactions is crucial for precise in vivo control of DNDDS.
• Nature provides inspiration for designing sophisticated DNDDS.

Purpose of the Study:

• To explore natural systems for insights into DNDDS design and function.
• To deepen the understanding of nano-bio interactions for fine control of DNDDS.
• To review state-of-the-art DNDDS designs, interactions, and functionalities.

Main Methods:

• Reviewing literature on DNDDS inspired by molecular, subcellular, and cellular levels in nature.
• Analyzing ingenious designs and controllable functionalities of DNDDS under various stimuli.
• Discussing assembly strategies and response mechanisms tailored to diseased microenvironments.

Main Results:

• Highlighting state-of-the-art DNDDS with controllable functionalities inspired by nature.
• Demonstrating how nano-bio interactions can be leveraged for precise DNDDS control.
• Showcasing tailored DNDDS assembly and response mechanisms for specific disease microenvironments.

Conclusions:

• Nature-inspired designs offer significant potential for advancing DNDDS.
• Further research into nano-bio interactions is key for optimizing DNDDS performance.
• Addressing current challenges will pave the way for future DNDDS innovations.