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Inhibitors Targeting YAP in Gastric Cancer: Current Status and Future Perspectives

Jiaxin Yong1, Yuan Li1, Sihan Lin1

  • 1Department of Surgical Oncology and General Surgery, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, Ministry of Education, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, 110001, People's Republic of China.

Drug Design, Development and Therapy
|June 18, 2021
PubMed

Insights

Gastric cancer (GC) involves the Hippo signaling pathway and its effector, Yes-associated protein (YAP). This review summarizes YAP inhibitors and their potential for treating GC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Signaling

Background:

  • Gastric cancer (GC) is a significant global health concern.
  • The Hippo signaling pathway is frequently deregulated in GC, influencing cancer progression.
  • Yes-associated protein (YAP), a key downstream effector, plays a critical role in GC development.

Purpose of the Study:

  • To review existing drugs and small-molecule inhibitors targeting YAP.
  • To discuss the therapeutic potential of YAP inhibitors in gastric cancer treatment.

Main Methods:

  • Literature review of studies on YAP inhibitors in gastric cancer.
  • Summary of reported drugs and compounds that inhibit YAP.
  • Analysis of clinical prospects for YAP-targeted therapies.

Main Results:

  • YAP is a crucial factor in GC proliferation, metastasis, and drug resistance.
  • Various drugs and small-molecule inhibitors targeting YAP have been identified.
  • These inhibitors show promise as potential therapeutic agents for GC.

Conclusions:

  • YAP is a vital drug target for gastric cancer.
  • YAP inhibitors represent a promising avenue for GC treatment.
  • Further clinical investigation of YAP inhibitors in GC is warranted.
Keywords:
Hippo pathwayYes-associated proteingastric adenocarcinomasmall molecule inhibitortargeted therapy

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