Related Experiment Video
Updated: Nov 1, 2025

Isolation of Tonsillar Mononuclear Cells to Study Ex Vivo Innate Immune Responses in a Human Mucosal Lymphoid Tissue
Published on: June 14, 2020
Methanobrevibacter smithii tonsillar phlegmon: a case report
Abstract:
Untreated tonsillar phlegmon is a life-threatening condition commonly caused by Streptococcus pyogenes and Fusobacterium necrophorum, among other pathogens. Here, using specific laboratory tools, we detected Methanobrevibacter smithii in addition to S. pyogenes. This unprecedented observation questions the role of methanogens in phlegmon and the optimal treatment of this mixed infection.
Insights
Untreated tonsillar phlegmon, a serious infection, was found to involve Methanobrevibacter smithii alongside Streptococcus pyogenes. This discovery challenges current understanding and treatment strategies for this mixed infection.
Area of Science:
- Microbiology
- Infectious Diseases
- Oral Medicine
Background:
- Tonsillar phlegmon is a severe throat infection.
- Commonly caused by Streptococcus pyogenes and Fusobacterium necrophorum.
- Requires prompt medical intervention.

