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Key Elements on the Pathway to HCV Elimination: Lessons Learned From the AASLD HCV Special Interest Group 2020

Jordan J Feld1, John W Ward2

  • 1Toronto Center for Liver DiseaseUniversity Health NetworkUniversity of TorontoTorontoONCanada.

Hepatology Communications
|June 18, 2021
PubMed

Insights

Despite advances in hepatitis C virus (HCV) treatment, most infections remain undiagnosed. Strategies for scaling up HCV testing and care, especially in marginalized populations, are crucial for elimination goals.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Public Health Policy

Background:

  • The World Health Organization has set ambitious viral hepatitis elimination goals, with a decade remaining.
  • Significant challenges persist in diagnosing and treating hepatitis C virus (HCV) infection, despite therapeutic advancements.
  • A large proportion of individuals with HCV remain undiagnosed and untreated, hindering elimination efforts.

Purpose of the Study:

  • To summarize key concepts from the 2020 American Association for the Study of Liver Diseases (AASLD) HCV Special Interest Group symposium.
  • To examine strategies for scaling up HCV testing and care delivery.
  • To explore novel approaches for HCV elimination and mortality reduction.

Main Methods:

  • Review of discussions and presentations from the 2020 AASLD Liver Meeting's HCV Special Interest Group symposium.
  • Analysis of policies and strategies for expanding HCV testing and treatment access.
  • Exploration of micro-elimination strategies and innovative care settings.

Main Results:

  • The symposium highlighted the need to expand HCV testing and treatment beyond specialty settings, integrating care into primary care and drug treatment programs.
  • Strategies for reaching marginalized populations, including persons who inject drugs, were emphasized for effective HCV elimination.
  • Discussions included the development of a hepatitis C vaccine and innovative organ transplantation approaches using HCV-viremic donors.

Conclusions:

  • Scaling up accessible HCV testing and treatment, particularly in non-traditional settings and for at-risk populations, is essential for achieving viral hepatitis elimination.
  • Innovative strategies, including micro-elimination and advancements in vaccine development and organ utilization, are vital components of comprehensive HCV control.
  • Addressing diagnostic and therapeutic gaps requires a multi-faceted approach involving policy changes and expanded care paradigms.

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