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Key genes and drug delivery systems to improve the efficiency of chemotherapy

Zally Torres-Martinez1, Yamixa Delgado2, Yancy Ferrer-Acosta3

  • 1Chemistry Department, University of Puerto Rico- Rio Piedras campus, San Juan, PR 00936, USA.

Cancer Drug Resistance (Alhambra, Calif.)
|June 18, 2021
PubMed

Insights

Cancer cells develop drug resistance through various mechanisms, impacting treatments like cisplatin and doxorubicin. Understanding gene expression and exploring nanocarriers can help overcome this resistance.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Cancer cells can develop resistance to anticancer drugs through diverse biological mechanisms.
  • Mechanisms include altered transmembrane proteins, DNA repair, target molecule changes, and genetic responses.
  • Commonly resistant drugs include cisplatin, doxorubicin, paclitaxel, and fluorouracil.

Purpose of the Study:

  • To review key regulatory genes and their expression in cancer drug resistance.
  • To examine cancer cell responses and regulation when exposed to anticancer drugs.
  • To discuss nanocarriers as a strategy to overcome anticancer drug resistance.

Main Methods:

  • Review of literature on cancer drug resistance mechanisms.
  • Analysis of gene expression patterns in resistant cancer cells.
  • Exploration of nanocarrier applications in overcoming drug resistance.

Main Results:

  • Drug resistance involves differential gene expression for cell adaptation and survival.
  • Specific genes and cancer types exhibit distinct resistance profiles.
  • Nanocarriers show potential for enhancing drug delivery and efficacy.

Conclusions:

  • Understanding gene regulation is crucial for combating cancer drug resistance.
  • Alternative therapeutic strategies, such as nanocarriers, are vital for treatment success.
  • Further research into nanocarrier-based therapies is warranted.
Keywords:
Cancer resistancedrug delivery systemsresistance genes

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