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Related Experiment Videos

First trimester fetal blood sampling.

F Orlandi1, C Jakil, G Damiani

  • 1Servizio di Diagnosi Prenatale, Osp. V. Cervello, Palermo.

Acta Europaea Fertilitatis
|January 1, 1988
PubMed
Summary
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First-trimester cordocentesis enables early prenatal diagnosis for conditions like thalassemia. This minimally invasive technique shows promise for fetal blood sampling and potential intrauterine therapies.

Area of Science:

  • Medical Science
  • Obstetrics & Gynecology
  • Fetal Medicine

Background:

  • Prenatal diagnosis is crucial for managing genetic and hematologic disorders.
  • First-trimester diagnostic procedures offer earlier intervention possibilities.
  • Cordocentesis, a fetal blood sampling technique, traditionally occurs later in pregnancy.

Purpose of the Study:

  • To evaluate the feasibility and safety of diagnostic cordocentesis in the first trimester.
  • To assess the utility of first-trimester cordocentesis for specific indications like thalassemia and karyotyping.
  • To explore potential advantages over chorionic villus sampling (CVS).

Main Methods:

  • Eight diagnostic cordocenteses were performed in the late first trimester.
  • Indications included thalassemia (5 cases) and karyotyping (3 cases).

Related Experiment Videos

  • A specific technique involving simultaneous probe and needle handling was employed for fetal blood collection (0.25-0.35 cc).

    • Main Results:

    • Successful blood sampling for diagnosis was achieved in all 8 cases.
    • One pregnancy was terminated based on diagnostic findings.
    • No complications were reported in the remaining 7 patients during a 3-week follow-up period.

    Conclusions:

    • First-trimester cordocentesis is a viable option for prenatal diagnosis, particularly for thalassemia.
    • The procedure offers potential advantages over CVS and opens avenues for intrauterine transplantation.
    • Further research is needed to fully establish the safety profile of early cordocentesis.