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Revealing Advanced Glycation End Products Associated Structural Changes in Serum Albumin

Alex Naftaly1, Roza Izgilov1, Eman Omari1

  • 1Department of Cell and Developmental Biology, Sackler School of Medicine, Tel Aviv University, Levanon St., P.O. Box 39040, Tel Aviv 6997801, Israel.

ACS Biomaterials Science & Engineering
|June 18, 2021
PubMed
Summary

Protein glycation, particularly by methylglyoxal (MGO) and glycolaldehyde (GAD), induces structural changes in serum albumin (SA), promoting amyloid fibril formation and aggregation under physiological conditions.

Keywords:
advanced glycation end productglycolaldehydemethylglyoxaloligomerizationprotein modificationstiffness

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