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Updated: Nov 1, 2025

Ultrasound-guided Botulinum Toxin-A Injections: A Method of Treating Sialorrhea
Published on: November 9, 2016
First bite syndrome treated with onabotulinumtoxin A injections
First bite syndrome (FBS) causes facial pain with eating. Onabotulinumtoxin A injections effectively treated FBS in a post-surgery patient, offering a promising new option for managing this condition.
Area of Science:
- Orofacial pain management
- Neuromodulation therapies
Background:
- First bite syndrome (FBS) is a distinct orofacial pain condition.
- Characterized by unilateral facial pain triggered by the first bite or taste of food.
- Requires awareness of clinical presentation and management strategies for healthcare providers.
Observation:
- A case study of a 43-year-old male patient with FBS is presented.
- The patient developed FBS following a partial parotidectomy for mucoepidermoid carcinoma.
- Orofacial pain was managed with onabotulinumtoxin A injections into residual parotid tissue.
Findings:
- Onabotulinumtoxin A demonstrated significant efficacy in alleviating FBS-associated pain.
- Treatment with onabotulinumtoxin A resulted in minimal adverse effects.
- Successful pain relief was achieved through targeted injections.
Implications:
- Onabotulinumtoxin A represents a promising therapeutic avenue for FBS management.
- Oral healthcare providers should consider onabotulinumtoxin A for patients with FBS.
- This treatment offers profound pain relief with a favorable safety profile.
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