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Related Concept Videos

Glaucoma: Overview01:25

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Related Experiment Video

Updated: Nov 1, 2025

Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography
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Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography

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Relationship between peripapillary vessel density and visual function based on Garway-Heath sectorization in

Jeong Min Kwon1, Keunheung Park2, Sangyoon Kim3

  • 1Department of Ophthalmology, Pusan Veterans Hospital, Busan, South Korea.

Indian Journal of Ophthalmology
|June 19, 2021
PubMed
Summary

Peripapillary vessel density (pVD) and retinal nerve fiber layer thickness (pRNFLT) correlate with visual field sensitivity (VFS) in glaucoma patients. These measurements, particularly in the inferotemporal sector, aid in understanding glaucoma

Keywords:
Glaucomaoptical coherence tomography angiographypapillomacular areaperipapillary vessel density

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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Medical Imaging

Background:

  • Glaucoma is a leading cause of irreversible blindness worldwide.
  • Understanding the structure-function relationship in glaucoma is crucial for early diagnosis and management.
  • Peripapillary vessel density (pVD) and retinal nerve fiber layer thickness (pRNFLT) are key indicators of glaucomatous damage.

Purpose of the Study:

  • To investigate the relationship between peripapillary vessel density (pVD) and visual field sensitivity (VFS).
  • To examine the correlation between peripapillary retinal nerve fiber layer thickness (pRNFLT) and VFS.
  • To analyze these relationships based on Garway-Heath sectorization in open-angle glaucoma patients.

Main Methods:

  • Inclusion of 66 eyes from healthy subjects and 84 eyes from glaucoma subjects.
  • Utilized standard automated perimetry and optical coherence tomography angiography for eye examinations.
  • Compared sectoral structure-function relationships using Garway-Heath sectorization across different glaucoma severity groups and performed multivariate analyses.

Main Results:

  • Statistically significant correlations were found between pVD-VFS and pRNFLT-VFS in the glaucoma group, independent of the VFS sector.
  • In glaucoma patients, temporal sector VFS was significantly related to pVD, pRNFLT, and age in a multivariate model (R² = 0.721).
  • Area under the receiver operating characteristic curves (AUROC) for pVD in the inferotemporal sector were comparable to pRNFLT across glaucoma severity groups.

Conclusions:

  • The significant relationship between pVD and VFS in the papillomacular area highlights its importance.
  • Measuring both pVD and pRNFLT in the corresponding areas is valuable for understanding paracentral field defects in glaucoma.
  • These findings contribute to expanding pathophysiologic knowledge of glaucoma.