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Related Experiment Videos

Twins and triplets with necrotizing enterocolitis.

T E Wiswell1, C T Hankins

  • 1Walter Reed Army Institute of Research, Washington, DC.

American Journal of Diseases of Children (1960)
|September 1, 1988
PubMed
Summary
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Birth order and asphyxia do not increase the risk of necrotizing enterocolitis (NEC) in multiple-gestation infants. Prematurity remains the primary risk factor for NEC development.

Area of Science:

  • Neonatalogy
  • Perinatal Medicine
  • Pediatric Surgery

Background:

  • Necrotizing enterocolitis (NEC) is a serious gastrointestinal condition affecting newborns.
  • Multiple-gestation pregnancies present unique considerations for infant health outcomes.

Purpose of the Study:

  • To investigate if birth order or other factors like asphyxia are significant risk factors for NEC.
  • To analyze NEC development in the context of multiple births.

Main Methods:

  • Retrospective review of 2856 multiple-gestation pregnancies from 1980-1985.
  • Identified 42 infants with NEC among twins and triplets.
  • Compared NEC incidence based on birth order and associated clinical features.

Main Results:

Related Experiment Videos

  • NEC occurred in 19% of firstborns and 23% of secondborns; no thirdborns developed NEC.
  • Secondborn infants had lower Apgar scores and needed more resuscitation but were not more prone to NEC.
  • Multiple gestation, birth order, feeding practices, and asphyxia were not associated with NEC development.

Conclusions:

  • Prematurity is the only consistent risk factor identified for NEC.
  • Birth order and other evaluated features do not appear to be significant risk factors for NEC in multiple-gestation infants.