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Tissue remodelling and increased DNA damage in patients with incompetent valves in chronic venous insufficiency

Miguel A Ortega1,2,3, Oscar Fraile-Martínez1, Cielo García-Montero1

  • 1Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, Spain.

Journal of Cellular and Molecular Medicine
|June 20, 2021
PubMed

Insights

Younger patients with chronic venous insufficiency (CVI) and valve incompetence exhibit DNA damage and inflammation. These findings suggest localized tissue changes in young CVI patients with venous reflux.

Area of Science:

  • Vascular Biology
  • Molecular Medicine
  • Pathophysiology

Background:

  • Chronic venous insufficiency (CVI) is a widespread condition affecting blood return to the heart.
  • Valve incompetence in CVI leads to blood reflux and venous hypertension.
  • The precise pathological mechanisms underlying CVI-related valve incompetence are not fully understood.

Purpose of the Study:

  • To investigate DNA damage, inflammation, and extracellular matrix remodeling in CVI-related valve incompetence.
  • To compare these molecular changes between younger and older CVI patients with and without venous reflux.

Main Methods:

  • Analysis of greater saphenous vein specimens from 110 CVI patients, categorized by age and presence of venous reflux.
  • Quantitative reverse transcription PCR (RT-qPCR) and immunohistochemistry were used to assess gene and protein expression.
  • Key markers analyzed included PARP (DNA damage), IL-17 (inflammation), COL-I, COL-III (collagen remodeling), MMP-2, and TIMP-2 (matrix metalloproteinases).

Main Results:

  • Younger CVI patients with venous reflux showed significantly elevated expression of PARP, IL-17, COL-I, COL-III, and MMP-2.
  • These patients also exhibited reduced TIMP-2 expression and a higher COL-I/III ratio.
  • The findings indicate chronic DNA damage and altered extracellular matrix in young CVI patients with valve incompetence.

Conclusions:

  • Young CVI patients with venous reflux experience chronic DNA damage.
  • These molecular alterations contribute to local tissue changes and may have systemic implications.
  • Ageing may be associated with these pathological processes in CVI.

Keywords:
PARPcellular damagematrix remodellingvalve incompetence

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