Related Experiment Video
Updated: Nov 1, 2025

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
Published on: July 24, 2021
[Hypersensitivity to β-lactam antibiotics: algorithms of management and desensitization as a vital therapeutic
Ricardo Cardona1, Luis Santamaría, Liliana Guevara-Saldaña
1Universidad de Antioquia, Grupo de Alergología Clínica y Experimental, Medellín, Colombia. rcv2016udea@gmail.com.
Abstract:
Hypersensitivity reactions can be complex and life-threatening to patients, especially when drugs such as β-lactam antibiotics are involved. To this day, there are diagnostic algorithms and mobile applications that improve the clinical approach, as well as laboratory tests and more specialized procedures, such as skin tests and controlled exposure tests; which are useful for identifying the drug involved and for selecting safe and effective therapeutic alternatives. For several years, the desensitization procedure has been positioned as a vital tool for clinical allergists and for their patients, and it is key to improving clinical outcomes such as survival and quality of life.
Related Concept Videos
Desensitization and Tachyphylaxis
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Development of Antibiotic Resistance
Hypersensitivities
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Antibiotic Selection
Acute Pyelonephritis II: Diagnostic Studies and Management

