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Strain differences in taste reactivity to NaCl.

H J Grill1, I L Bernstein

  • 1Department of Psychology, University of Pennsylvania, Philadelphia 19104.

The American Journal of Physiology
|September 1, 1988
PubMed
Summary
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Rats show distinct taste preferences for salt (NaCl). These differences are due to taste factors, not post-oral influences, but disappear when sodium is deficient.

Area of Science:

  • Neuroscience
  • Physiology
  • Behavioral Science

Background:

  • Strain differences in salt (NaCl) preference exist between Fischer 344 (F-344) and Wistar rats.
  • Previous preference tests suggested these differences might involve taste or post-oral factors.

Purpose of the Study:

  • To differentiate between taste and post-oral factors influencing NaCl preference in F-344 and Wistar rats.
  • To investigate the effect of sodium deficiency on these strain differences.

Main Methods:

  • Utilized the taste reactivity test to measure oral motor responses to NaCl.
  • Administered furosemide to induce sodium deficiency in both rat strains.
  • Assessed ingestive and aversive behaviors in response to various chemical stimuli.

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Main Results:

  • Taste reactivity tests revealed significant strain differences in oral motor responses to NaCl when sodium-replete, supporting taste-based factors.
  • These strain differences in NaCl response disappeared under sodium deficiency.
  • Both strains exhibited a sodium appetite when deficient, as shown by intake and preference measures.

Conclusions:

  • NaCl preference differences between F-344 and Wistar rats are primarily taste-driven when sodium-replete.
  • Sodium deficiency overrides these taste-based strain differences, inducing a universal sodium appetite.
  • Taste reactivity is a valuable tool for dissecting sensory and physiological influences on ingestive behavior.