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Author Spotlight: Development of a Smartphone-Enhanced Paper-Based Device for Rapid Dengue NS1 Detection

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Handheld plasmonic biosensor for virus detection in field-settings.

Arif E Cetin¹, Zeynep A Kocer^1,2, Seda Nur Topkaya³

¹Izmir Biomedicine and Genome Center, Balcova, Izmir, 35340, Turkey.

Sensors and Actuators. B, Chemical

|June 21, 2021

Summary

This study presents a portable, label-free biosensor for rapid virus detection in the field. The device uses plasmonic nanohole arrays and lensfree imaging, achieving a low limit of detection for early pandemic response.

Keywords:

Label-free biosensing Lensfree-imaging Nanotechnology Plasmonics Point-of-care diagnostics

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Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Published on: February 16, 2018

Area of Science:

Nanotechnology and Biosensing
Medical Diagnostics
Field-Portable Instrumentation

Background:

The COVID-19 pandemic highlighted the urgent need for rapid, field-deployable diagnostic kits.
Existing diagnostic tools often require bulky, expensive equipment, limiting their use in resource-poor settings.
Label-free detection methods are crucial for simplifying diagnostics and reducing costs.

Purpose of the Study:

To introduce a lightweight, field-portable biosensor for label-free virus detection.
To demonstrate the biosensor's capability for detecting medically relevant viral concentrations.
To develop a user-friendly system for rapid diagnosis in diverse settings.

Main Methods:

A plasmonic chip with nanohole arrays integrated into a lensfree-imaging framework.
Utilized a complementary metal-oxide-semiconductor (CMOS) camera and a tunable light-emitting diode (LED) source.
Developed a low-cost sample preparation kit and a Python-based graphical user interface (GUI).

Main Results:

Successfully demonstrated label-free detection of H1N1 virus (swine flu) at relevant concentrations.
Achieved a limit of detection (LOD) as low as 10^3 TCID50/mL.
The handheld platform weighs only 70g and is 12cm tall.

Conclusions:

The developed biosensor offers accurate, rapid, and portable virus detection.
Its antibody-based detection scheme allows for easy adaptation to various viral targets (e.g., COVID-19, influenza).
This technology is a strong candidate for diagnostic applications in resource-limited areas, aiding in early disease containment.