Blood glucose related to pregnancy induced hypertension syndrome

To investigate the incidence of hyperglycemia caused by abnormal glucose metabolism during pregnancy and the relationship between abnormal glucose metabolism and pregnancy induced hypertension (PIH).

734 pregnant females were assigned into the PIH group (n=284) and the normal group (n=304). We examined fasting blood glucose (FBG), 1 hour postprandial blood glucose, 2-hour postprandial blood glucose, fasting insulin (FINS), 1 hour postprandial insulin, 2 hour postprandial insulin, triglyceride (TG), total cholesterol (TC), Hemoglobin A1c (HbA1c) and Insulin sensitivity index (ISI), at the same time, we recorded the SBP, DBP, BMI of each pregnant women.

The fasting blood glucose, 1 hour postprandial blood glucose and 2 hours postprandial blood glucose in the PIH group were higher than those in the normal group (P<0.05). And insulin sensitivity index and hemoglobin Alc (HbA1c) in the PIH group was statistically significant compared with the normal group during 24-28 weeks of gestation.

Our results demonstrated that abnormal glucose metabolism in second trimester may be related to higher risk of PIH, and hyperglycemia may be one of the important factors of pregnancy induced hypertension.