Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neuroplasticity01:01

Neuroplasticity

1.0K
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
1.0K
Neural Regulation01:37

Neural Regulation

40.7K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
40.7K
Long-term Potentiation01:35

Long-term Potentiation

56.7K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
56.7K
Long-term Potentiation01:25

Long-term Potentiation

3.0K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
3.0K
Associative Learning01:27

Associative Learning

773
Associative learning is a fundamental concept in behavioral psychology, wherein a connection is established between two stimuli or events, leading to a learned response. This process is critical in understanding how behaviors are acquired and modified. Conditioning, the mechanism through which associations are formed, can be divided into two main types: classical conditioning and operant conditioning, each elucidating different aspects of associative learning.
Classical conditioning, also known...
773
Role of Neurotransmitters in Memory01:23

Role of Neurotransmitters in Memory

1.7K
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
 Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sense of agency and decision making.

Frontiers in psychology·2026
Same author

Sense of agency and addiction.

Frontiers in psychology·2026
Same author

Is there a criterion in criterial learning? Insights from studying feedback delays.

Journal of experimental psychology. Learning, memory, and cognition·2026
Same author

Context modulates brain state dynamics and behavioral responses during narrative comprehension.

Imaging neuroscience (Cambridge, Mass.)·2026
Same author

Context modulates brain state dynamics and behavioral responses during narrative comprehension.

bioRxiv : the preprint server for biology·2025
Same author

Just do it: A neuropsychological theory of agency, cognition, mood, and dopamine.

Journal of experimental psychology. General·2024

Related Experiment Video

Updated: Nov 1, 2025

A Fully Automated and Highly Versatile System for Testing Multi-cognitive Functions and Recording Neuronal Activities in Rodents
09:13

A Fully Automated and Highly Versatile System for Testing Multi-cognitive Functions and Recording Neuronal Activities in Rodents

Published on: May 3, 2012

14.5K

Modulation of Dopamine for Adaptive Learning: A Neurocomputational Model.

Jeffrey B Inglis1, Vivian V Valentin2, F Gregory Ashby2

  • 1Interdepartmental Graduate Program in Dynamical Neuroscience, University of California, Santa Barbara.

Computational Brain & Behavior
|June 21, 2021
PubMed
Summary

This study introduces a biologically detailed neural circuit model for adaptive learning rates, modulating dopamine responses to reward prediction errors. The model successfully replicates experimental findings, offering insights into brain-based learning mechanisms.

Keywords:
adaptive learning ratecomputational cognitive neurosciencedopamineventral subiculum

More Related Videos

Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice
09:35

Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice

Published on: January 20, 2015

9.0K
In Vivo Optical Calcium Imaging of Learning-Induced Synaptic Plasticity in Drosophila melanogaster
06:35

In Vivo Optical Calcium Imaging of Learning-Induced Synaptic Plasticity in Drosophila melanogaster

Published on: October 8, 2019

9.3K

Related Experiment Videos

Last Updated: Nov 1, 2025

A Fully Automated and Highly Versatile System for Testing Multi-cognitive Functions and Recording Neuronal Activities in Rodents
09:13

A Fully Automated and Highly Versatile System for Testing Multi-cognitive Functions and Recording Neuronal Activities in Rodents

Published on: May 3, 2012

14.5K
Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice
09:35

Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice

Published on: January 20, 2015

9.0K
In Vivo Optical Calcium Imaging of Learning-Induced Synaptic Plasticity in Drosophila melanogaster
06:35

In Vivo Optical Calcium Imaging of Learning-Induced Synaptic Plasticity in Drosophila melanogaster

Published on: October 8, 2019

9.3K

Area of Science:

  • Computational neuroscience
  • Neurobiology
  • Machine learning

Background:

  • Previous models of adaptive learning rates in the brain lack biological detail.
  • Understanding the neural circuitry of adaptive learning is crucial for neuroscience.

Purpose of the Study:

  • To propose a biologically detailed computational model of adaptive learning rates.
  • To describe a neural circuit that modulates dopamine response gain for adaptive learning.

Main Methods:

  • Developed a spiking neuron model of a neural circuit.
  • Simulated dopamine signal generation based on neuron population size and firing rate.
  • Validated the model against single-neuron recording and voltammetry data.

Main Results:

  • The model successfully generated dopamine signals dependent on tonic and phasic activity.
  • Model predictions aligned with experimental results from neuroscience studies.
  • Demonstrated a neural circuit mechanism for adaptive learning rates.

Conclusions:

  • The proposed neural circuit provides a biologically plausible mechanism for adaptive learning rates.
  • The model offers a framework for understanding dopamine's role in learning.
  • The model's principles may apply to a broader range of dopamine-mediated cognitive tasks.