Related Experiment Video

Updated: Nov 1, 2025

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
09:41

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells

Published on: July 15, 2015

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Drug and Solute Transporters in Mediating Resistance to Novel Therapeutics in Multiple Myeloma

Rachel L Mynott1, Craig T Wallington-Beddoe1,2,3,4

  • 1College of Medicine and Public Health, Flinders University, Bedford Park, South Australia 5042, Australia.

ACS Pharmacology & Translational Science
|June 21, 2021
PubMed

Insights

Multiple myeloma treatment resistance is a major challenge. This review explores how drug transporters, like ATP-binding cassette and solute carrier transporters, contribute to resistance against novel therapies in multiple myeloma.

Area of Science:

  • Hematology
  • Oncology
  • Molecular Biology

Background:

  • Multiple myeloma is an incurable plasma cell cancer.
  • Novel therapies like proteasome inhibitors and immunomodulatory drugs improve survival but face resistance.
  • Mechanisms of resistance to traditional chemotherapy, involving ATP-binding cassette transporters, are known, but their role in novel therapy resistance is unclear.

Purpose of the Study:

  • To review the role of drug and solute transporters in mediating resistance to novel therapies for multiple myeloma.
  • To evaluate the contribution of ATP-binding cassette and solute carrier transporters to treatment resistance.

Main Methods:

  • Literature review of studies on multiple myeloma, drug resistance, and transporter proteins.
  • Analysis of existing data on the expression and function of ATP-binding cassette and solute carrier transporters in multiple myeloma cells.
  • Evaluation of the impact of these transporters on response to proteasome inhibitors and immunomodulatory drugs.

Main Results:

  • ATP-binding cassette transporters may contribute to resistance against novel multiple myeloma therapies.
  • Solute carrier transporters are implicated in cancer drug resistance through altered cell homeostasis.
  • Abnormal expression and solute transport by SLC transporters can influence multiple myeloma cell drug sensitivity.

Conclusions:

  • Transporter proteins, including ABC and SLC families, are critical factors in multiple myeloma drug resistance.
  • Understanding transporter-mediated resistance is essential for developing strategies to overcome treatment failure.
  • Targeting specific transporters may offer new therapeutic avenues for overcoming resistance in multiple myeloma.

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