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Marla Sokolowski Retrospectively.

Harold L Atwood1

  • 1Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Canada.

Journal of Neurogenetics
|June 21, 2021
PubMed
Summary

Marla Sokolowski discovered a behavioral polymorphism in fruit fly larvae, linking

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Area of Science:

  • Behavioral Genetics
  • Genetics and Genomics
  • Neuroscience

Background:

  • Marla Sokolowski's research career is highlighted, focusing on her foundational discovery in behavioral genetics.
  • Her work with fruit flies (Drosophila melanogaster) identified a behavioral polymorphism in larvae.
  • This polymorphism was traced to alleles of a single gene, 'foraging'.

Discussion:

  • The 'foraging' gene encodes a cyclic GMP kinase.
  • This kinase is expressed in various tissues in both larval and adult fruit flies.
  • Subsequent research elucidated genetic and environmental influences on behavioral variation.

Key Insights:

  • Discovery of 'sitter' and 'rover' larvae, representing distinct feeding behaviors.
  • Establishing a direct link between a specific gene ('foraging') and a complex behavior.
  • Demonstrating the role of a cyclic GMP kinase in mediating behavioral differences.

Outlook:

  • Continued exploration of genetic and environmental interactions shaping behavior.
  • Investigating the broader implications of the 'foraging' gene in neurobiology.
  • Building upon Sokolowski's legacy in understanding the genetic basis of behavior.
Keywords:
Drosophilabehavioural geneticsfeeding behaviourgene-environment interactions

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