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[Antitumor activity of CPT-11 against rat Walker 256 carcinoma]
T Furuta1, T Yokokura, M Mutai
1Yakult Central Institute for Microbiological Research.
Gan to Kagaku Ryoho. Cancer & Chemotherapy
|September 1, 1988
Abstract:
The antitumor activity of CPT-11 on rat Walker 256 carcinoma was investigated. Intraperitoneal, intravenous or oral administration of CPT-11 caused a remarkable prolongation of the life span of Wistar rat implanted with Walker 256 intraperitoneally. Intravenous injection and oral administration of CPT-11 markedly inhibited the growth of subcutaneously implanted Walker 256. CPT-11 showed a considerable antitumor activity by continuous intravenous injection against the solid type Walker 256.