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Evaluation of Protein–Protein Interactions using an On-Membrane Digestion Technique
07:07

Evaluation of Protein–Protein Interactions using an On-Membrane Digestion Technique

Published on: July 19, 2019

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Soluble resistance-related calcium-binding protein participates in multiple diseases via protein-protein interactions

Yinmiao Wang1, Yuanyuan Zhu1, Zhangya Pu2

  • 1Department of Blood Transfusion, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan Province 410008, China; NHC Key Laboratory of Cancer Proteomics, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan Province 410008, China.

Biochimie
|June 21, 2021
PubMed

Insights

Soluble resistance-related calcium-binding protein (sorcin) is a multifunctional protein involved in calcium signaling. This review highlights sorcin

Area of Science:

  • Biochemistry and Molecular Biology
  • Cellular Physiology
  • Disease Pathogenesis

Background:

  • Soluble resistance-related calcium-binding protein (sorcin) is a penta-EF-hand protein crucial for calcium (Ca2+) homeostasis and signaling.
  • Sorcin's interactions with diverse proteins are fundamental to its regulatory functions across cellular processes.
  • While extensively studied in cancer and multidrug resistance, sorcin's roles in non-neoplastic diseases are increasingly recognized.

Purpose of the Study:

  • To review and summarize the diverse roles of sorcin in various non-neoplastic diseases.
  • To elucidate the mechanisms by which sorcin exerts its functions, primarily through protein-protein interactions (PPIs).
  • To provide a comprehensive understanding of sorcin's multifunctional characteristics in a broader pathological context.

Main Methods:

  • Literature review of recent studies focusing on sorcin's involvement in non-neoplastic diseases.
  • Analysis of reported sorcin interaction partners and their functional implications.
  • Synthesis of information on sorcin's regulatory roles in conditions like cardiomyopathy, diabetes, neurodegeneration, liver diseases, and viral infections.

Main Results:

  • Sorcin interacts with a wide array of proteins, including Ca2+ channels, receptors, stress markers, and viral proteins.
  • These interactions mediate sorcin's involvement in diverse pathological conditions beyond cancer.
  • Specific examples include sorcin's interaction with sarcoplasmic reticulum/endoplasmic reticulum Ca2+ ATPase, tau, and viral proteins.

Conclusions:

  • Sorcin is a critical multifunctional protein with significant roles in various non-neoplastic diseases.
  • Understanding sorcin's protein-protein interaction network is key to deciphering its pathological contributions.
  • Further research into sorcin's functions in these diseases may reveal novel therapeutic targets.
Keywords:
CardiomyopathyLiver diseaseNeurodegenerative diseaseProtein-protein interactionSorcinType 2 diabetes mellitus

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