Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pleiotropy01:33

Pleiotropy

41.8K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
41.8K
Unrenewable Cells00:50

Unrenewable Cells

2.6K
In humans, the photoreceptor cells of the eye and sensory hair cells of the ear lack stem cells. These cells are thus unrenewable and cannot be replaced when they are damaged or destroyed.
Photoreceptors
The retina is composed of several layers and contains specialized cells called photoreceptors. The photoreceptors (rods and cones) change their membrane potential when stimulated by light energy. There are two types of photoreceptors—rods and cones—which differ in the shape of...
2.6K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

35.8K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
35.8K
Hearing01:31

Hearing

54.6K
When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.
54.6K
Anatomy of the Ear01:16

Anatomy of the Ear

9.5K
Auditory sensation, commonly called hearing, involves the transformation of sonic waves into neural impulses facilitated by the structures of the auditory organ. The prominent, flesh-like structure on the side of the head, called the auricle, directs sound waves towards the auditory canal. The auricle is often mislabeled as the pinna, a term more aligned with mobile structures like a feline's external ear. The auditory canal penetrates the cranium via the external auditory meatus of the...
9.5K
Genetic Lingo01:11

Genetic Lingo

108.7K
Overview
108.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lesion network localization of depression in multiple sclerosis.

Nature. Mental health·2026
Same author

Inflammatory and Infectious Cutaneous Entities Resembling Cutaneous T-Cell Lymphoma (CTCL): An Integrated Clinicopathological Review.

Dermatopathology (Basel, Switzerland)·2026
Same author

No Child Left Behind: Advancing Access in Pediatric Dermatology, a 4-Year, Single-Center Experience.

Pediatric clinics of North America·2026
Same author

Leveraging Whole-Exome Sequencing to Decipher the Genetic Landscape of Three Genodermatoses' Cases in Middle Eastern Pediatric Patients.

Genes·2026
Same author

A Multifaceted Holistic Review of the Literature on Scar Dermatoses.

International wound journal·2026
Same author

Response to Cherng-En Hwang and Ho, "Preferential CD123 expression in granuloma annulare compared to necrobiosis lipoidica and sarcoidosis".

Journal of the American Academy of Dermatology·2026
Same journal

Hypoactive Sexual Desire Disorder in Menopausal Women: Dermatologic Implications of Antiandrogen and Testosterone Therapy.

Journal of the American Academy of Dermatology·2026
Same journal

Incise parallel, section perpendicular to the dermatoglyphs for diagnosis of acral melanocytic lesions-A comment on Thakker et al.

Journal of the American Academy of Dermatology·2026
Same journal

Response to Xue et al, "Defining super-responders is not the same as predicting rituximab response in pemphigus".

Journal of the American Academy of Dermatology·2026
Same journal

Comment on Nie et al. (2026) 'Suicidality Reports in Acne Patients Treated with Isotretinoin and Concomitant Antidepressants: A Descriptive Analysis of FDA Adverse Event Reporting System Data'.

Journal of the American Academy of Dermatology·2026
Same journal

Defining super-responders is not the same as predicting rituximab response in pemphigus.

Journal of the American Academy of Dermatology·2026
Same journal

Eosinophilic fasciitis induced by checkpoint inhibitors: a retrospective multicenter case-series, comparison with eosinophilic fasciitis unrelated to checkpoint inhibition and literature review.

Journal of the American Academy of Dermatology·2026
See all related articles

Related Experiment Video

Updated: Nov 1, 2025

Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages
09:09

Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages

Published on: April 11, 2025

1.2K

Genodermatoses with hearing impairment.

Lamiaa Hamie1, Edward Eid1, Samar Khalil1

  • 1Department of Dermatology, American University of Beirut Medical Centre, Beirut, Lebanon.

Journal of the American Academy of Dermatology
|June 21, 2021
PubMed
Summary
This summary is machine-generated.

Hearing loss is common in genodermatoses. Recognizing ear abnormalities aids dermatologists in diagnosing and managing these genetic skin disorders, improving patient outcomes.

Keywords:
cutaneous manifestationsdeafnessgenodermatosesinherited skin disorderssyndromic hearing loss

More Related Videos

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
09:44

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss

Published on: January 25, 2016

19.5K
Author Spotlight: Advancements in Cultivating Mouse Hair Cells for Auditory Research
06:07

Author Spotlight: Advancements in Cultivating Mouse Hair Cells for Auditory Research

Published on: September 15, 2023

3.0K

Related Experiment Videos

Last Updated: Nov 1, 2025

Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages
09:09

Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages

Published on: April 11, 2025

1.2K
Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
09:44

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss

Published on: January 25, 2016

19.5K
Author Spotlight: Advancements in Cultivating Mouse Hair Cells for Auditory Research
06:07

Author Spotlight: Advancements in Cultivating Mouse Hair Cells for Auditory Research

Published on: September 15, 2023

3.0K

Area of Science:

  • Dermatology
  • Otolaryngology
  • Genetics

Background:

  • Hearing loss is a frequent manifestation of genodermatoses.
  • Auditory deficits are often overlooked, potentially leading to diagnostic errors by dermatologists.
  • Understanding ear anatomy and embryology is crucial for recognizing associated genetic disorders.

Purpose of the Study:

  • To review the anatomical, developmental, and embryological features of the ear.
  • To summarize genodermatoses associated with auditory deficits.
  • To provide diagnostic algorithms for dermatologists managing these conditions.

Main Methods:

  • Literature review of genodermatoses with auditory findings.
  • Classification of disorders based on embryological origin or clinical presentation.
  • Development of clinical algorithms for diagnosis and management.

Main Results:

  • Genodermatoses with auditory involvement were categorized into neural crest, metabolic, pigmentary, craniofacial, and miscellaneous groups.
  • Key anatomical and embryological aspects of the ear relevant to these disorders were detailed.
  • Diagnostic algorithms were proposed to assist dermatologists.

Conclusions:

  • Dermatologists must appreciate the link between skin and ear manifestations in genodermatoses.
  • Early recognition of auditory deficits is vital for accurate diagnosis and appropriate management.
  • The provided algorithms can enhance the dermatological approach to genodermatoses with ear involvement.