Related Experiment Video
Updated: Nov 1, 2025

Intrathecal Application of a Fluorescent Dye for the Identification of Cerebrospinal Fluid Leaks in Cochlear Malformation
Published on: February 29, 2020
Surgical Correction of a Clivus Cerebrospinal Fluid Fistula: A Technical Report
Alexey Nikolaevich Shkarubo1, Dmitry Nikolaevich Andreev1, Ilia Valerievich Chernov1
1Department of Neurosurgery, N.N. Burdenko National Medical Research Center of Neurosurgery, Moscow, Russian Federation.
Background:
Cerebrospinal fistulas of the clivus region often result from previous surgical intervention at the skull base. The localization and size of the fistula determine the appropriate treatment strategy. When flap closure is not possible, the microsuture technique with autograft placement provides a favorable outcome.
Methods:
We present a technical report on the application of the microsuture technique for clivus region cerebrospinal fluid fistula closure in a patient with previous chordoma treatment and nonspecific coronavirus disease 2019 complications.
Results:
The application of the microsuture technique resulted in stable remission of the fistula and complete regression of the clinical manifestations.
Conclusions:
The microsuture technique for clivus region fistula closure is a potentially valuable alternative to vascularized flap closure.

