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Related Concept Videos

Overview of Transposition and Recombination02:13

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Transposons make up a significant part of genomes of various organisms. Therefore, it is believed that transposition played a major evolutionary role in speciation by changing genome sizes and modifying gene expression patterns. For example, in bacteria, transposition can lead to conferring antibiotic resistance. Movement of transposable elements within the genetic pool of pathogenic bacteria can aid in transfer of antibiotic-resistant genetic elements. In eukaryotes, transposons can carry out...
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The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
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DNA-only transposons are called autonomous transposons since they code for the enzyme transposase that is required for the transposition mechanism. Insertion of transposons can alter gene functions in multiple ways. They can mutate the gene, alter gene expression by introducing a novel promoter or insulator sequence, introduce new splice sites, and change the mRNA transcripts produced, or remodel chromatin structure.
The donor site from where the transposon is excised is either degraded or...
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Transposons, or "jumping genes," are small mobile genetic elements (MGEs) that range from 700 to 40,000 base pairs in length. They are found in all organisms and can move within the same chromosome or transfer to different chromosomes. In some cases, transposons can also jump between different host DNA molecules, such as plasmids or viruses, contributing to genetic variability.Barbara McClintock first discovered these mobile genetic elements in the 1940s while studying maize genetics, and she...
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Related Experiment Video

Updated: Nov 1, 2025

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TE Hub: A community-oriented space for sharing and connecting tools, data, resources, and methods for transposable

, Tyler A Elliott1, Tony Heitkam2

  • 1Centre for Biodiversity Genomics, University of Guelph, Guelph, ON, Canada.

Mobile DNA
|June 22, 2021
PubMed
Summary

Transposable elements (TEs) are vital in eukaryotic genomes. TE Hub is a new community resource simplifying TE research by centralizing tools, methods, and communication for easier integration and standardization.

Keywords:
AnnotationClassificationCollaborationCommunityDatabaseSoftwareTransposable elements

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Area of Science:

  • Genomics
  • Molecular Biology
  • Evolutionary Biology

Background:

  • Transposable elements (TEs) are pervasive in eukaryotic genomes, influencing evolution and function.
  • Extensive research has yielded numerous TE databases, software, and annotation guidelines.
  • The proliferation of TE resources presents compatibility challenges and can overwhelm researchers.

Discussion:

  • TE Hub is a new, community-driven platform addressing the need for centralized TE resources.
  • It integrates a website (tehub.org), social media (Twitter, Slack), and regular video updates.
  • The platform aims to foster collaboration, improve resource integration, and standardize methods.

Key Insights:

  • TE Hub provides a unified space for documenting and developing TE research tools and protocols.
  • It facilitates communication and collaboration within the transposable element research community.
  • The resource promotes standardization and effectiveness of diverse TE analysis methods.

Outlook:

  • TE Hub aims to become a foundational resource for improved integration and standardization of TE tools.
  • The platform invites broad community participation to expand its scope and utility.
  • Future development will focus on enhancing the effectiveness and accessibility of TE research resources.