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The emerging role of gut microbiota in cardiovascular diseases

Dilip Kumar1, Sanjeev S Mukherjee1, Rabin Chakraborty1

  • 1Medica Institute of Cardiac Sciences, Kolkata, India.

Indian Heart Journal
|June 22, 2021
PubMed

Insights

Gut microbiota dysbiosis is linked to cardiovascular diseases (CVD). Understanding these links can lead to new treatments targeting the gut microbiome for better CVD management.

Area of Science:

  • Microbiology
  • Cardiology
  • Metabolic Diseases

Background:

  • Growing evidence links gut microbiota dysbiosis to cardiovascular diseases (CVD).
  • Dysbiosis is associated with hypertension, type 2 diabetes, obesity, dyslipidemia, atherosclerosis, heart failure, and atrial fibrillation.

Purpose of the Study:

  • To comprehensively review the pathogenetic mechanisms of gut dysbiosis in CVD.
  • To discuss therapeutic implications of targeting the gut microbiome in CVD management.

Main Methods:

  • Literature review of pathogenetic mechanisms.
  • Synthesis of current understanding of gut microbiota's role in CVD.

Main Results:

  • Gut dysbiosis contributes to the pathogenesis of various cardiovascular conditions.
  • Specific mechanisms linking dysbiosis to CVD risk factors are elucidated.

Conclusions:

  • A deeper understanding of gut microbiota-CVD links is crucial.
  • Novel microbiota-based therapeutic targets for CVD management can be developed.

Keywords:
Cardiovascular diseasesDiabetesGut microbiotaHypertensionObesityShort-chain fatty acids

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