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Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
Published on: August 28, 2018
Correlation between echocardiographic calcium score and coronary artery lesion severity on invasive coronary
Suhas Hardas1, Pritam Titar1, Ishwar Zanwar1
1Dept. of Cardiology, Poona Hospital & Research Centre, Pune, India.
Insights
Echocardiographic non-coronary calcium score (ECS) positively correlates with Gensini score, indicating increased lesion severity in coronary artery disease. Higher ECS values predict more severe coronary artery disease.
Area of Science:
- Cardiology
- Medical Imaging
- Diagnostic Tools
Background:
- Non-coronary calcium scoring via echocardiography (ECS) lacks direct correlation data with invasive coronary angiography (ICA) lesion severity.
- Assessing coronary artery disease (CAD) severity often relies on invasive methods like ICA.
Purpose of the Study:
- To investigate the direct correlation between Echocardiographic non-coronary calcium score (ECS) and coronary lesion severity as measured by the Gensini score.
- To evaluate the association of ECS with traditional cardiovascular risk factors.
Main Methods:
- One hundred seventy adult patients undergoing clinically indicated ICA were included.
- Standard transthoracic echocardiography was performed to calculate ECS and Gensini scores.
- Spearman's correlation analysis assessed the relationship between ECS and Gensini scores; ROC analysis determined ECS cut-off values.
Main Results:
- A significant positive correlation was found between total ECS and Gensini score (r=0.550, p<0.0001).
- Increasing ECS values were associated with higher Gensini scores, indicating greater coronary lesion severity.
- An ECS >1 demonstrated 56.5% sensitivity and 79.5% specificity for detecting CAD, with higher Gensini scores observed in patients with ECS >1.
Conclusions:
- The study confirms a statistically significant positive correlation between Echocardiographic non-coronary calcium score (ECS) and Gensini score.
- ECS emerges as a potential non-invasive marker for assessing the severity of coronary artery disease.
Objectives:
The direct correlation between Echocardiographic non-coronary calcium score (ECS) and lesion severity on invasive coronary angiography (ICA) is not reported. The aim of the present study was to find the correlation between ECS and Gensini score.
Methods:
One hundred seventy patients aged ≥18 years posted for clinically indicated ICA were included. All the patients underwent standard transthoracic echocardiography. ECS and Gensisni scores were calculated. The primary outcome measure was to find a correlation of ECS with Gensini score, whereas the secondary outcome measure was to correlate ECS with traditional risk factors for coronary artery disease. The Chi-square/Fisher exact test was used to compare qualitative variables. Spearman's correlation analysis was used for assessing the correlation between ECS score and the Gensini score. Receiver-operating characteristic curve analysis was performed to detect the cut-off value of the ECS score.
Results:
The correlation of total ECS with Gensini score was positive and statistically significant (r = 0.550, p-value < 0.0001). As ECS increased, the Gensini score increased. ECS value of >1 detected CAD with 56.5% sensitivity, 79.5% specificity. Eight-nine percent of patients who had ECS >1, had Gensini score ≥18, whereas 44.3% of patients who had ECS ≤1, had Gensini score ≥18. The patients with ECS >1 had significantly higher Gensini scores than the patients with ECS ≤1.
Conclusions:
The correlation of total ECS with Gensini score was positive and statistically significant.
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