Compilation of selenium metabolite data in selenized yeasts
Kelly L LeBlanc1, Zoltán Mester1
1National Research Council Canada, 1200 Montreal Road, Ottawa, Ontario, Canada.
Metallomics : Integrated Biometal Science
|June 22, 2021
Summary
Selenium-enriched yeast offers chemo-preventative benefits due to unique selenium metabolites beyond selenomethionine. Research is identifying and cataloging these diverse selenium species for better understanding.
Area of Science:
- Nutritional Biochemistry
- Analytical Chemistry
- Biotechnology
Background:
- Selenium-enriched yeast is a known selenium source with potential chemo-preventative properties.
- Selenomethionine constitutes the majority of selenium (60-84%) in these yeasts.
- The remaining 16-40% of selenium exists as various unique metabolites requiring characterization.
Purpose of the Study:
- To discuss analytical methods for identifying and quantifying selenium metabolites in enriched yeast.
- To present a new online database of identified selenium species, their structures, and mass spectral data.
Main Methods:
- Review of analytical techniques for selenium metabolite analysis.
- Creation and curation of an online database for selenium species.
Main Results:
- Nearly 100 unique selenium-containing metabolites have been identified in Saccharomyces cerevisiae.
- A comprehensive database (DOI: 10.4224/40001921) of these metabolites, including structures and spectral features, has been established.
Conclusions:
- Further research into the non-selenomethionine selenium species in enriched yeast is crucial.
- The developed database serves as a valuable resource for researchers studying selenium biochemistry and its health benefits.
