[Local application of recombinant activated factor VII for massive surgical bleeding]

Area of Science:

• Neurosurgery
• Hemostasis
• Oncology

Background:

• Anaplastic convexital meningioma resection can involve significant blood loss.
• Controlling intraoperative hemorrhage is critical in neurosurgical procedures.
• Traditional hemostatic methods may be insufficient for massive bleeding during tumor resection.

Purpose of the Study:

• To describe the local application of recombinant activated factor VII (coagil) for managing intractable bleeding during meningioma resection.
• To evaluate the efficacy of local recombinant activated factor VII in a neurosurgical context.

Main Methods:

• A standard tachocomb plate was moistened with a diluted solution of recombinant activated factor VII (coagil).
• The moistened plate was applied directly to the bleeding site for 5 minutes during meningioma resection.
• Finger pressure was subsequently replaced with a permanent napkin to maintain hemostasis.

Main Results:

• Massive bleeding occurred during the final stage of meningioma resection, unresponsive to traditional methods.
• Local application of recombinant activated factor VII (coagil) effectively controlled the bleeding.
• Hemostasis was achieved and maintained after the application of the factor.

Conclusions:

• Local application of recombinant activated factor VII (coagil) represents a potentially effective strategy for managing severe intraoperative bleeding in neurosurgery.
• This case report is the first to describe the local use of recombinant activated factor VII in neurosurgical patients.
• Further research is warranted to explore the safety and efficacy of this localized hemostatic approach.