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Updated: Nov 1, 2025

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Visible-Light-Induced Trifluoromethylation of Allylic Alcohols
Bowen Li1, Wubing Zeng1, Lin Wang1
1School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, P. R. China.
Abstract:
An organic photoredox-catalyzed dehydroxylative trifluoromethylation of allylic alcohols was developed in an environmentally benign manner. In this reaction, the readily available CF3SO2Na was selected as the trifluoromethylation reagent. The in situ generated byproduct SO2 was reutilized to activate C-OH bond, which enabled this dehydroxylative trifluoromethylation to be performed conveniently. A variety of multifunctionalized CF3-allylic compounds were obtained in high yields and excellent stereoselectivity.
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