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Updated: Nov 1, 2025

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
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STING and liver disease.

Can Chen1, Rui-Xia Yang1, Hua-Guo Xu2

  • 1Department of Laboratory Medicine, The First Affiliated Hospital, Nanjing Medical University, 300 Guang Zhou Road, Nanjing, 210029, Jiangsu Province, China.

Journal of Gastroenterology
|June 23, 2021
PubMed
Summary
This summary is machine-generated.

The stimulator of interferon genes (STING) pathway plays a dual role in liver diseases. Modulating STING activity offers therapeutic potential for viral hepatitis, metabolic disorders, and hepatocellular carcinoma.

Keywords:
Hepatocellular carcinomaLiver fibrosis and cirrhosisNon-alcoholic fatty liver diseaseSTINGViral hepatitis

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Area of Science:

  • Immunology
  • Hepatology
  • Molecular Biology

Background:

  • STING (stimulator of interferon genes), also known as TMEM173, is a cytoplasmic DNA sensor.
  • STING activation triggers innate and adaptive immune responses via IRF3 and NF-κB pathways.
  • STING is crucial for maintaining liver homeostasis, particularly in non-parenchymal cells.

Purpose of the Study:

  • To review the identified interactions between STING and various liver diseases.
  • To explore therapeutic strategies targeting the STING pathway in liver conditions.

Main Methods:

  • Literature review of STING's role in viral hepatitis, metabolic liver diseases, and hepatocellular carcinoma.
  • Analysis of STING's dual functions in different liver disease contexts.
  • Discussion of STING pathway modulation for therapeutic interventions.

Main Results:

  • STING activation inhibits viral hepatitis by initiating immune responses.
  • Aberrant STING activation promotes inflammation and metabolic disorders in metabolic liver diseases.
  • STING exhibits contradictory roles in hepatocellular carcinoma, potentially promoting or inhibiting cancer progression depending on immune cell context.

Conclusions:

  • STING signaling is intricately linked to liver disease pathogenesis.
  • Targeting the STING pathway presents a promising therapeutic avenue for managing diverse liver ailments.