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PERIODONTAL RESPONSE TO CYTOSTATIC DRUGS IN CHILDREN.

Yuliia V Popelo1, Pavlo I Tkachenko1, Natalia M Lokhmatova1

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Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|June 23, 2021
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Cytostatic drugs used in treating children with malignant tumors negatively impact oral hygiene and periodontal tissues. Careful dental care and monitoring are crucial during chemotherapy to mitigate these effects.

Keywords:
childrenmalignant tumorsperiodontitispolychemotherapystomatotoxicity

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Area of Science:

  • Pediatric Oncology
  • Periodontology
  • Oral Medicine

Background:

  • Children with malignant tumors undergo chemotherapy, potentially affecting oral health.
  • The periodontium is susceptible to damage from cytostatic agents.

Purpose of the Study:

  • To investigate the impact of various cytostatic drugs on the periodontium in pediatric cancer patients.
  • To assess changes in oral hygiene and gingival tissues during antitumor therapy.

Main Methods:

  • Examination of 44 pediatric patients with abdominal malignant tumors.
  • Analysis of oral hygiene, periodontal tissue condition, and gingival epithelial differentiation.

Main Results:

  • Chemotherapy significantly worsens oral hygiene and periodontal health without proper dental care.
  • Destructive changes in gingival epithelium and increased inflammatory cells observed.
  • Severity of oral issues correlates with cytostatic drug type and dosage.

Conclusions:

  • Antitumor therapy in children with cancer leads to decreased oral hygiene and destructive gingival changes.
  • The extent of oral disorders is dose- and type-dependent for cytostatic drugs.
  • Treatment and preventive strategies must account for these drug-induced oral side effects.