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Updated: Nov 1, 2025
Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
Published on: November 10, 2013
Two mixed valence diruthenium(II,III) isomeric complexes show different anticancer properties
Elisabetta Barresi1, Iogann Tolbatov2, Tiziano Marzo1
1Department of Pharmacy, University of Pisa, Via Bonanno Pisano, 6, 56126, Pisa, Italy. tiziano.marzo@unipi.it sabrina.taliani@unipi.it and CISUP-Centro per l'Integrazione della Strumentazione Scientifica dell'Università di Pisa, University of Pisa, Italy.
Abstract:
In this paper it is demonstrated that the nature of the ligands of two Ru2(ii,iii) paddlewheel complexes dramatically affects the overall anticancer properties in cells. Herein, the complex [Ru2(EB776)4Cl] was found to be more active against a glioblastoma model with respect to its isomer [Ru2(EB106)4Cl]. These different effects depend on the steric hindrance, on the allowed conformations of the complexes and on the presence of hydrophilic regions in [Ru2(EB776)4Cl], which overall lead to a lower "steric protection".
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