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[Treatment of melanoma with immune checkpoints inhibitors]

Jeremy Lupu1, Pierre Hamann1, Émilie Routier1

  • 1Service de dermatologie, institut Gustave-Roussy, Villejuif, France.

La Revue Du Praticien
|June 23, 2021
PubMed

Treatment of melanoma with immune checkpoints inhibitors .Immunotherapy with checkpoints inhibitors stimulates the anti-tumor response. It has dramatically changed the prognosis of advanced melanoma and other cancers. Anti-PD1, alone or in combination with anti-CTLA4, has demonstrated significantly better response and overall survival rates than chemotherapy. The immuno-mediated toxicity is more frequent and more serious with the combination of anti-PD1 and anti-CTLA4, which also appears as the most effective treatment for metastatic melanoma. Adjuvant anti-PD1 therapy is also effective in preventing recurrence in patients with resected stage III or IV melanoma. Studies are underway to evaluate this treatment in a neo-adjuvant situation and in localized melanomas with high risk of recurrence (stage II) with promising results.

Keywords:
ImmunotherapyMelanoma

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