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Updated: Nov 1, 2025
07:29
Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
11.8K
["Immunotherapy in head and neck squamous cell carcinoma"]
Grégoire Marret1, Édith Borcoman1, Christophe Le Tourneau2
1"Department of Drug Development and Innovation (D3i), Institut Curie, Paris et Saint-Cloud, France".
La Revue Du Praticien
|June 23, 2021
Summary
Immune checkpoint inhibitors are now standard for recurrent head and neck squamous cell carcinoma. Nivolumab and pembrolizumab offer approved immunotherapy options for advanced disease, with specific criteria for use.
Area of Science:
- Oncology
- Immunology
- Head and Neck Cancer Research
Background:
- Immune checkpoint inhibitors (ICIs) represent a significant advancement in cancer treatment.
- Head and neck squamous cell carcinoma (HNSCC) is a challenging disease with limited options for recurrent or metastatic cases.
Purpose of the Study:
- To outline the current standards of care for immunotherapy in recurrent and/or metastatic HNSCC.
- To detail the approved ICI regimens and their specific indications.
Main Methods:
- Review of recent clinical trial data and regulatory approvals for ICIs in HNSCC.
- Analysis of treatment guidelines for Nivolumab and Pembrolizumab in advanced HNSCC.
Main Results:
- Nivolumab is approved as a single agent for recurrent/metastatic HNSCC post-platinum therapy, irrespective of PD-L1 status.
- Pembrolizumab is approved in combination with chemotherapy or as a single agent for first-line recurrent/metastatic HNSCC, contingent on PD-L1 expression and prior treatment response.
Conclusions:
- ICIs have become the standard of care for specific patient populations with advanced HNSCC.
- Treatment decisions for immunotherapy in HNSCC involve patient selection based on disease status, prior therapies, and PD-L1 expression.
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