Related Experiment Video

Updated: Nov 1, 2025

Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells MSCs
06:20

Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells MSCs

Published on: December 24, 2015

12.5K

Aging and Mesenchymal Stem Cells: Therapeutic Opportunities and Challenges in the Older Group

Huan Chen1, Ousheng Liu1, Sijia Chen1

  • 1Hunan Key Laboratory of Oral Health Research, Hunan 3D Printing Engineering Research Center of Oral Care, Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Xiangya Stomatological Hospital, and Xiangya School of Stomatology, Central South University, Changsha, China.

Gerontology
|June 23, 2021
PubMed

Insights

Cellular senescence impairs mesenchymal stem cells (MSCs) in older adults, reducing MSC therapy effectiveness. Understanding senescence in MSCs is key to improving regenerative treatments for the elderly.

Area of Science:

  • Gerontology and Regenerative Medicine
  • Cellular Biology and Aging

Background:

  • Cellular senescence, a state of irreversible growth arrest, increases with age and contributes to age-related diseases.
  • Mesenchymal stem cells (MSCs) are crucial for tissue regeneration, but their efficacy declines in older individuals.
  • The aging microenvironment and cellular senescence negatively impact MSC number and function.

Purpose of the Study:

  • To investigate the effects of aging on MSCs.
  • To characterize the changes in senescent MSCs.
  • To discuss strategies for enhancing MSC therapy in the elderly population.

Main Methods:

  • Review of existing literature on cellular senescence and MSCs in aging.
  • Analysis of the functional and characteristic alterations in senescent MSCs.
  • Discussion of current and potential therapeutic interventions.

Main Results:

  • Aging leads to an accumulation of senescent cells, including MSCs.
  • Senescent MSCs exhibit impaired regenerative capacity and altered functionality.
  • The aging microenvironment exacerbates MSC dysfunction.

Conclusions:

  • Cellular senescence is a significant factor limiting the success of MSC therapy in the elderly.
  • Targeting senescence in MSCs or the microenvironment may improve therapeutic outcomes.
  • Further research is needed to optimize MSC applications for age-related conditions.
Keywords:
Aged groupAntiagingCellular senescenceMesenchymal stem cell therapyMesenchymal stem cells

More Related Videos

Mesenchymal Stromal Cell Culture and Delivery in Autologous Conditions: A Smart Approach for Orthopedic Applications10:30

Mesenchymal Stromal Cell Culture and Delivery in Autologous Conditions: A Smart Approach for Orthopedic Applications

Published on: December 8, 2016

10.2K
Isolation and Characterization of Mesenchymal Stromal Cells from Human Umbilical Cord and Fetal Placenta07:06

Isolation and Characterization of Mesenchymal Stromal Cells from Human Umbilical Cord and Fetal Placenta

Published on: April 3, 2017

47.7K

Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
5.2K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.3K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.9K
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
5.7K
Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
31.0K