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Millifluidics for Chemical Synthesis and Time-resolved Mechanistic Studies
Published on: November 27, 2013
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Microfluidic synthesis of high-valence programmable atom-like nanoparticles for reliable sensing
Jing Li1, Huayi Shi1, Runzhi Chen1
1Laboratory of Nanoscale Biochemical Analysis, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University Suzhou 215123 China houyuwang@suda.edu.cn yaohe@suda.edu.cn.
Chemical Science
|June 24, 2021
Summary
We developed a new method using microfluidics to create high-valence programmable atom-like nanoparticles (PANs) with high yields. This enables a fully automated platform for reliable sensing applications.
Area of Science:
- Nanotechnology
- Materials Science
- Analytical Chemistry
Background:
- Synthesizing programmable atom-like nanoparticles (PANs) with high valences and yields is challenging.
- Existing methods lack efficiency and control for advanced applications.
Purpose of the Study:
- To develop a novel microfluidic strategy for synthesizing high-valence PANs.
- To create an automated analytical platform for reliable sensing using these PANs.
Main Methods:
- Microfluidic galvanic displacement (μ-GD) coupled with microfluidic DNA nanoassembly.
- Synthesis of single-stranded DNA encoder (SSE)-encoded PANs.
- Development of an integrated microfluidic platform for sensor construction, sample loading, and on-line monitoring.
Main Results:
- Achieved high yields (>80%) for PANs with high valences (n=12).
- Demonstrated the first PAN-based automatic analytical platform for reliable quantitative measurements.
- Accurately determined tetracycline (TET) in serum and milk with high recovery (~100%) and low RSD (<5.0%).
Conclusions:
- The μ-GD and DNA nanoassembly approach enables efficient synthesis of high-valence PANs.
- The integrated microfluidic platform offers a robust solution for automated and reliable SERS sensing.
- This technology has significant potential for sensitive and quantitative analysis in complex samples.
