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Updated: Nov 1, 2025

Controlling the Size, Shape and Stability of Supramolecular Polymers in Water
Published on: August 2, 2012
Supramolecular adducts between macrocyclic Gd(iii) complexes and polyaromatic systems: a route to enhance the
Enza Di Gregorio1, Luciano Lattuada2, Alessandro Maiocchi2
1Molecular Imaging Center, Department of Molecular Biotechnologies and Health Sciences, University of Torino Via Nizza 52 Torino 10126 Italy giuseppe.ferrauto@unito.it.
Abstract:
The set-up of reversible binding interactions between the hydrophobic region of macrocyclic GBCAs (Gadolinium Based Contrast Agents) and SO3 -/OH containing pyrene derivatives provides new insights for pursuing relaxivity enhancements of this class of MRI contrast agents. The strong binding affinity allows attaining relaxation enhancements up to 50% at pyrene/GBCA ratios of 3 : 1. High resolution NMR spectra of the Yb-HPDO3A/pyrene system fully support the formation of a supramolecular adduct based on the set-up of hydrophobic interactions. The relaxation enhancement may be accounted for in terms of the increase of the molecular reorientation time (τ R) and the number of second sphere water molecules. This effect is maintained in blood serum and in vivo, as shown by the enhancement of contrast in T 1w-MR images obtained by simultaneous injection of GBCA and pyrene derivatives in mice.
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