Quantitative Analysis of Tranexamic Acid Effects on Ecchymosis in Rhinoplasty.

Area of Science:

• Plastic Surgery
• Ophthalmology
• Hematology

Background:

• Postoperative ecchymosis is a common concern in rhinoplasty.
• Tranexamic acid (TXA) is a controversial agent for reducing bruising.
• Potential serious side effects of TXA include seizures, blood clots, and vision changes.

Purpose of the Study:

• To evaluate the efficacy of tranexamic acid (TXA) in reducing postoperative ecchymosis following primary rhinoplasty.
• To compare ecchymosis levels between patients receiving TXA and a control group.

Main Methods:

• Prospective study involving 100 primary rhinoplasty patients (March 2019 - June 2019).
• 50 patients received TXA (intravenous and intraoperative injections), 50 served as controls.
• Postoperative ecchymosis was objectively quantified using Adobe Photoshop and RGB/L*a*b* color scales on postoperative day 7.

Main Results:

• No statistically significant differences in postoperative ecchymosis were observed between the TXA group and the control group across all color metrics (p > 0.05).
• No adverse events were reported in patients who received tranexamic acid.

Conclusions:

• Tranexamic acid (TXA) did not demonstrate efficacy in reducing postoperative ecchymosis in primary rhinoplasty patients in this study.
• The use of TXA via intravenous and intraoperative routes did not provide a significant benefit for bruising reduction in rhinoplasty.