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Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
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Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
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Intracranial Meningiomas Decrease in Volume on Magnetic Resonance Imaging After Discontinuing Progestin.

Eduard H J Voormolen1, Pierre Olivier Champagne1, Elena Roca1

  • 1Department of Neurosurgery, Lariboisiere Hospital, University of Paris Diderot, Paris, France.

Neurosurgery
|June 24, 2021
PubMed
Summary
This summary is machine-generated.

Progestin therapy with cyproterone acetate (PCA) influences intracranial meningioma growth. Stopping PCA treatment caused most meningiomas to shrink or stabilize, indicating a significant change in tumor behavior.

Keywords:
MeningiomaProgestinVolumetric MRI

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Area of Science:

  • Neuro-oncology
  • Endocrinology

Background:

  • The effect of progestin therapy on meningiomas is not well understood.
  • Intracranial meningiomas are tumors that can be influenced by hormonal factors.

Purpose of the Study:

  • To examine the relationship between the growth patterns of intracranial meningiomas and the use of cyproterone acetate (PCA).

Main Methods:

  • Prospective study of 108 women with 262 intracranial meningiomas, documenting PCA use.
  • Magnetic resonance imaging (MRI) was used to measure meningioma volume changes and growth velocities after PCA cessation.

Main Results:

  • Ninety-one percent of meningiomas regressed or stabilized after stopping PCA.
  • Meningioma growth velocity significantly changed from growth during PCA use (0.25 mm³/day) to shrinkage after withdrawal (-0.54 mm³/day).

Conclusions:

  • Intracranial meningiomas in patients using PCA show significant regression or stabilization upon PCA discontinuation.
  • PCA significantly impacts meningioma growth kinetics, promoting growth during use and shrinkage after withdrawal.