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Related Experiment Video

Updated: Nov 1, 2025

High Spatial Resolution Chemical Imaging of Implant-Associated Infections with X-ray Excited Luminescence Chemical Imaging Through Tissue

High Spatial Resolution Chemical Imaging of Implant-Associated Infections with X-ray Excited Luminescence Chemical Imaging Through Tissue

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Edge-illumination x-ray phase-contrast imaging.

Alessandro Olivo¹

¹Department of Medical Physics and Biomedical Engineering, UCL, London, United Kingdom.

Journal of Physics. Condensed Matter : an Institute of Physics Journal

|June 24, 2021

Summary

Edge-illumination X-ray phase-contrast imaging (XPCI) now offers practical applications without synchrotrons. This advancement makes advanced XPCI accessible for broader scientific and real-world uses.

Keywords:

phase-contrast structured illumination x-ray imaging x-ray masks

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Area of Science:

Medical Imaging
Materials Science
Physics

Background:

X-ray phase-contrast imaging (XPCI) gained prominence in the 1990s with synchrotron facilities.
Early XPCI required synchrotrons or micro-focal sources, limiting accessibility.
XPCI reveals features invisible to conventional X-rays, offering significant scientific potential.

Purpose of the Study:

To trace the evolution of X-ray phase-contrast imaging (XPCI).
To highlight advancements enabling XPCI with conventional X-ray sources.
To present the current state and practical applications of edge-illumination XPCI.

Main Methods:

Review of XPCI development and technological breakthroughs.
Focus on edge-illumination XPCI as a key advancement.
Analysis of contemporary XPCI research and practical implementations.

Main Results:

Development of XPCI methods independent of synchrotron radiation.
Emergence of edge-illumination XPCI as a viable technique.
Demonstration of XPCI's transition towards practical, real-world applications.

Conclusions:

Edge-illumination XPCI overcomes previous limitations of XPCI systems.
This technique facilitates broader adoption of XPCI in various scientific fields.
XPCI is moving from specialized facilities to more accessible applications.