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The Cervical Sympathetic Trunk-Submandibular Gland Axis Modulates Neutrophil and Mast Cell Functions
International Archives of Allergy and Immunology
|June 25, 2021
Summary
Superior cervical ganglia (SCG) removal affects neutrophil responses and lung inflammation in rats. Submandibular gland removal reverses these effects, highlighting a complex sympathetic nervous system-immune interaction.
Area of Science:
- Neuroimmunology
- Autonomic Nervous System
- Inflammatory Response
Background:
- The superior cervical ganglia (SCG) are key components of the sympathetic nervous system.
- Neutrophilia and inflammatory responses are critical in parasitic infections.
- Mast cells play a role in allergic and inflammatory reactions.
Purpose of the Study:
- To investigate the role of the superior cervical ganglia (SCG) and submandibular glands in regulating neutrophil function and pulmonary inflammation.
- To elucidate the mechanisms by which the cervical sympathetic trunk-submandibular axis influences immunological responses.
Main Methods:
- Superior cervical ganglia (SCG) decentralization and ganglionectomy in rats.
- Submandibular gland removal (sialadenectomy).
- Antigen challenge in Nippostrongylus brasiliensis-sensitized rats.
- Assessment of neutrophil chemotaxis and pulmonary neutrophilia.
- Measurement of TNF-α release from mast cells.
Main Results:
- SCG denervation reduced neutrophil chemotaxis and pulmonary neutrophilia post-antigen challenge.
- Submandibular gland removal reversed the denervation-induced changes in neutrophil function.
- Reduced TNF-α release from mast cells in decentralized and sialadenectomized rats was abolished when both procedures were combined.
Conclusions:
- The cervical sympathetic trunk-submandibular axis is involved in modulating neutrophil function and inflammatory responses.
- Multiple mechanisms mediate the influence of this axis on the immune system.
- These findings suggest a significant interplay between the autonomic nervous system and immune cell behavior.
Keywords:
ChemotaxisMast cellsNeutrophilsPulmonary inflammationSalivary glandsSuperior cervical gangliaTNF-αMore Related Videos
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