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Updated: Nov 1, 2025

Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography
Published on: July 10, 2018
Noninvasive Analysis of Lung Function in Small Animals: Compressed Air, Thoracic Gas Volume, Airway Resistance,
Abstract:
We present a noninvasive and highly sensitive system for measuring lung function in small animals. It is based on a two-chambered body plethysmography. Head and body chambers are separated by a cuff around the head of the animal. Aerosols for pharmacologic investigations are generated. Breathing-dependent changes in pressure and/or volume are registered, the signals are digitized. All data are processed in an IBM compatible PC/AT. A multitasking real time operation system shows the signals on line. A special software offers seven different lung function parameters (compressed air, airway resistance, thoracic gas volume, maximal flow rates, tidal volume, breathing frequency, I/E ratio). The results are presented as graph and text documents. Result files are submitted to calculation by standard soft ware. The computer-aided handling allows the simultaneous performance of up to nine pharmacological tests.
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